Please note: Your browser does not support the features used on Addgene\'s website. You may not be able to create an account or request plasmids through this website until you upgrade your browser. Learn more A myelopoiesis-associated regulatory intergenic noncoding RNA transcript within the human HOXA cluster. Zhang X, Lian Z, Padden C, Gerstein MB, Rozowsky J, Snyder M, Gingeras TR, Kapranov P, Weissman SM, Newburger PE. Blood. 2009 Mar 12;113(11):2526-34. doi: 10.1182/blood-2008-06-162164. Epub 2009 Jan 14. Aire regulates the expression of differentiation-associated genes and self-renewal of embryonic stem cells. Neurons efficiently repair glutamate-induced oxidative DNA damage by a process involving CREB-mediated up-regulation of apurinic endonuclease 1. J Biol Chem. 2010 Sep 3;285(36):28191-9. doi: 10.1074/jbc.M109.082883. Epub 2010 Jun 23. Syntaxin 3 is necessary for cAMP- and cGMP-regulated exocytosis of CFTR: implications for enterotoxigenic diarrhea. Am J Physiol Cell Physiol. 2010 Dec;299(6):C1450-60. doi: 10.1152/ajpcell.00029.2010. Epub 2010 Sep 15. ATR and ATRIP are recruited to herpes simplex virus type 1 replication compartments even though ATR signaling is disabled. S1P lyase regulates DNA damage responses through a novel sphingolipid feedback mechanism. Hypoxic preconditioning enhances bone marrow mesenchymal stem cell migration via Kv2.1 channel and FAK activation. Am J Physiol Cell Physiol. 2011 Aug;301(2):C362-72. doi: 10.1152/ajpcell.00013.2010. Epub 2011 May 11. Stable knockdown of MYCN by lentivirus-based RNAi inhibits human neuroblastoma cells growth in vitro and in vivo. Biochem Biophys Res Commun. 2011 Jul 1;410(2):364-70. doi: 10.1016/j.bbrc.2011.06.020. Epub 2011 Jun 12. Loss of transcription factor KLF5 in the context of p53 ablation drives invasive progression of human squamous cell cancer. Cancer Res. 2011 Oct 15;71(20):6475-84. doi: 10.1158/0008-5472.CAN-11-1702. Epub 2011 Aug 25. DNA mismatch repair proteins are required for efficient herpes simplex virus 1 replication. A Wnt/beta-catenin negative feedback loop inhibits interleukin-1-induced matrix metalloproteinase expression in human articular chondrocytes. Sensing adenovirus infection: activation of interferon regulatory factor 3 in RAW 264.7 cells. Negative regulation of RhoA translation and signaling by hnRNP-Q1 affects cellular morphogenesis. Myosin Ia is required for CFTR brush border membrane trafficking and ion transport in the mouse small intestine. Traffic. 2012 Aug;13(8):1072-82. doi: 10.1111/j.1600-0854.2012.01368.x. Epub 2012 May 8. Stem Cells Dev. 2012 Oct 10;21(15):2878-90. doi: 10.1089/scd.2012.0097. Epub 2012 Jun 11. Inhibition of Akt potentiates 2-DG-induced apoptosis via downregulation of UPR in acute lymphoblastic leukemia. Mol Cancer Res. 2012 Jul;10(7):969-78. doi: 10.1158/1541-7786.MCR-12-0125. Epub 2012 Jun 12. Cell-specific regulation of nucleic acid sensor cascades: a controlling interest in the antiviral response. Notch3 and Mef2c proteins are mutually antagonistic via Mkp1 protein and miR-1/206 microRNAs in differentiating myoblasts. J Biol Chem. 2012 Nov 23;287(48):40360-70. doi: 10.1074/jbc.M112.378414. Epub 2012 Oct 10. Am J Physiol Cell Physiol. 2012 Dec 15;303(12):C1292-300. doi: 10.1152/ajpcell.00259.2012. Epub 2012 Oct 17. Silencing alpha1,3-fucosyltransferases in human leukocytes reveals a role for FUT9 enzyme during E-selectin-mediated cell adhesion. J Biol Chem. 2013 Jan 18;288(3):1620-33. doi: 10.1074/jbc.M112.400929. Epub 2012 Nov 28. RNA-interacting proteins act as site-specific repressors of ADAR2-mediated RNA editing and fluctuate upon neuronal stimulation. Nucleic Acids Res. 2013 Feb 1;41(4):2581-93. doi: 10.1093/nar/gks1353. Epub 2012 Dec 28. Liu C, Cheng H, Shi S, Cui X, Yang J, Chen L, Cen P, Cai X, Lu Y, Wu C, Yao W, Qin Y, Liu L, Long J, Xu J, Li M, Yu X. Curr Mol Med. 2013 May;13(4):467-78. Up-regulation of MBD1 promotes pancreatic cancer cell epithelial-mesenchymal transition and invasion by epigenetic down-regulation of E-cadherin. RIF1 is essential for 53BP1-dependent nonhomologous end joining and suppression of DNA double-strand break resection. Chapman JR, Barral P, Vannier JB, Borel V, Steger M, Tomas-Loba A, Sartori AA, Adams IR, Batista FD, Boulton SJ. Mol Cell. 2013 Mar 7;49(5):858-71. doi: 10.1016/j.molcel.2013.01.002. Epub 2013 Jan 17. Acta Biochim Biophys Sin (Shanghai). 2013 Apr;45(4):303-8. doi: 10.1093/abbs/gmt011. Epub 2013 Feb 17. Polycomb Cbx family members mediate the balance between haematopoietic stem cell self-renewal and differentiation. Klauke K, Radulovic V, Broekhuis M, Weersing E, Zwart E, Olthof S, Ritsema M, Bruggeman S, Wu X, Helin K, Bystrykh L, de Haan G. Nat Cell Biol. 2013 Apr;15(4):353-62. doi: 10.1038/ncb2701. Epub 2013 Mar 17. Silencing of MBD1 reverses pancreatic cancer therapy resistance through inhibition of DNA damage repair. Xu J, Zhu W, Xu W, Cui X, Chen L, Ji S, Qin Y, Yao W, Liu L, Liu C, Long J, Li M, Yu X. Int J Oncol. 2013 Jun;42(6):2046-52. doi: 10.3892/ijo.2013.1901. Epub 2013 Apr 16. T cell factor 4 is a pro-catabolic and apoptotic factor in human articular chondrocytes by potentiating nuclear factor kappaB signaling. J Biol Chem. 2013 Jun 14;288(24):17552-8. doi: 10.1074/jbc.M113.453985. Epub 2013 Apr 19. EED and KDM6B coordinate the first mammalian cell lineage commitment to ensure embryo implantation. Baird BN, Schliekelman MJ, Ahn YH, Chen Y, Roybal JD, Gill BJ, Mishra DK, Erez B, O Reilly M, Yang Y, Patel M, Liu X, Thilaganathan N, Larina IV, Dickinson ME, West JL, Gibbons DL, Liu DD, Kim MP, Hicks JM, Wistuba II, Hanash SM, Kurie JM. PLoS One. 2013 Jun 10;8(6):e67054. doi: 10.1371/journal.pone.0067054. Print 2013. Cyclin-dependent kinase 1-dependent phosphorylation of cAMP response element-binding protein decreases chromatin occupancy. J Biol Chem. 2013 Aug 16;288(33):23765-75. doi: 10.1074/jbc.M113.464057. Epub 2013 Jun 27. The RNA-binding protein fused in sarcoma (FUS) functions downstream of poly(ADP-ribose) polymerase (PARP) in response to DNA damage. J Biol Chem. 2013 Aug 23;288(34):24731-41. doi: 10.1074/jbc.M113.497974. Epub 2013 Jul 5. LIN28A facilitates the transformation of human neural stem cells and promotes glioblastoma tumorigenesis through a pro-invasive genetic program. Mao XG, Hutt-Cabezas M, Orr BA, Weingart M, Taylor I, Rajan AK, Odia Y, Kahlert U, Maciaczyk J, Nikkhah G, Eberhart CG, Raabe EH. Oncotarget. 2013 Jul;4(7):1050-64. Specificity protein 4 functionally regulates the transcription of NMDA receptor subunits GluN1, GluN2A, and GluN2B. Biochim Biophys Acta. 2013 Dec;1833(12):2745-56. doi: 10.1016/j.bbamcr.2013.07.002. Epub 2013 Jul 18. Sal-like 4 (SALL4) suppresses CDH1 expression and maintains cell dispersion in basal-like breast cancer. FEBS Lett. 2013 Sep 17;587(18):3115-21. doi: 10.1016/j.febslet.2013.07.049. Epub 2013 Aug 14. Berbamine inhibits the growth of liver cancer cells and cancer-initiating cells by targeting Ca(2)(+)/calmodulin-dependent protein kinase II. Meng Z, Li T, Ma X, Wang X, Van Ness C, Gan Y, Zhou H, Tang J, Lou G, Wang Y, Wu J, Yen Y, Xu R, Huang W. Mol Cancer Ther. 2013 Oct;12(10):2067-77. doi: 10.1158/1535-7163.MCT-13-0314. Epub 2013 Aug 19. Neuron-specific specificity protein 4 bigenomically regulates the transcription of all mitochondria- and nucleus-encoded cytochrome c oxidase subunit genes in neurons. BDNF and exercise enhance neuronal DNA repair by stimulating CREB-mediated production of apurinic/apyrimidinic endonuclease 1. Neuromolecular Med. 2014 Mar;16(1):161-74. doi: 10.1007/s12017-013-8270-x. Epub 2013 Oct 10. Sphingosine phosphate lyase regulates myogenic differentiation via S1P receptor-mediated effects on myogenic microRNA expression. de la Garza-Rodea AS, Baldwin DM, Oskouian B, Place RF, Bandhuvula P, Kumar A, Saba JD. FASEB J. 2014 Jan;28(1):506-19. doi: 10.1096/fj.13-233155. Epub 2013 Oct 24. Regulation of Na(+)/K(+)-ATPase by neuron-specific transcription factor Sp4: implication in the tight coupling of energy production, neuronal activity and energy consumption in neurons. Pore-exposed tyrosine residues of P-glycoprotein are important hydrogen-bonding partners for drugs. Donmez Cakil Y, Khunweeraphong N, Parveen Z, Schmid D, Artaker M, Ecker GF, Sitte HH, Pusch O, Stockner T, Chiba P. Mol Pharmacol. 2014 Mar;85(3):420-8. doi: 10.1124/mol.113.088526. Epub 2013 Dec 23. Plakoglobin but not desmoplakin regulates keratinocyte cohesion via modulation of p38MAPK signaling. J Invest Dermatol. 2014 Jun;134(6):1655-64. doi: 10.1038/jid.2014.21. Epub 2014 Jan 17. A novel immunomodulatory function of PHLPP1: inhibition of iNOS via attenuation of STAT1 ser727 phosphorylation in mouse macrophages. Alamuru NP, Behera S, Butchar JP, Tridandapani S, Kaimal Suraj S, Babu PP, Hasnain SE, Ehtesham NZ, Parsa KV. J Leukoc Biol. 2014 Jan 17. LSD1 sustains pancreatic cancer growth via maintaining HIF1alpha-dependent glycolytic process. Cancer Lett. 2014 Jun 1;347(2):225-32. doi: 10.1016/j.canlet.2014.02.013. Epub 2014 Feb 18. Specificity protein 4 (Sp4) regulates the transcription of AMPA receptor subunit GluA2 (Gria2). Biochim Biophys Acta. 2014 Jun;1843(6):1196-206. doi: 10.1016/j.bbamcr.2014.02.008. Epub 2014 Feb 24. Stathmin, interacting with Nf-kappaB, promotes tumor growth and predicts poor prognosis of pancreatic cancer. SAA1 polymorphisms are associated with variation in antiangiogenic and tumor-suppressive activities in nasopharyngeal carcinoma. Lung HL, Man OY, Yeung MC, Ko JM, Cheung AK, Law EW, Yu Z, Shuen WH, Tung E, Chan SH, Bangarusamy DK, Cheng Y, Yang X, Kan R, Phoon Y, Chan KC, Chua D, Kwong DL, Lee AW, Ji MF, Lung ML. Oncogene. 2015 Feb 12;34(7):878-89. doi: 10.1038/onc.2014.12. Epub 2014 Mar 10. Sphingosine Phosphate Lyase Regulates Murine Embryonic Stem Cell Proliferation and Pluripotency through an S1P/STAT3 Signaling Pathway. Generation and characterization of induced pluripotent stem cells from Aid-deficient mice. PLoS One. 2014 Apr 9;9(4):e94735. doi: 10.1371/journal.pone.0094735. eCollection 2014. Adaptations of energy metabolism associated with increased levels of mitochondrial cholesterol in Niemann-Pick type C1-deficient cells. J Biol Chem. 2014 Jun 6;289(23):16278-89. doi: 10.1074/jbc.M114.559914. Epub 2014 Apr 30. Tenascin-X promotes epithelial-to-mesenchymal transition by activating latent TGF-beta. Alcaraz LB, Exposito JY, Chuvin N, Pommier RM, Cluzel C, Martel S, Sentis S, Bartholin L, Lethias C, Valcourt U. J Cell Biol. 2014 May 12;205(3):409-28. doi: 10.1083/jcb.201308031. Cytoplasmic localization of p21 protects trophoblast giant cells from DNA damage induced apoptosis. PLoS One. 2014 May 21;9(5):e97434. doi: 10.1371/journal.pone.0097434. eCollection 2014. Inhibition of glutathione peroxidase mediates the collateral sensitivity of multidrug-resistant cells to tiopronin. Hall MD, Marshall TS, Kwit AD, Miller Jenkins LM, Dulcey AE, Madigan JP, Pluchino KM, Goldsborough AS, Brimacombe KR, Griffiths GL, Gottesman MM. J Biol Chem. 2014 Aug 1;289(31):21473-89. doi: 10.1074/jbc.M114.581702. Epub 2014 Jun 14. Chen LZ, Li XY, Huang H, Xing W, Guo W, He J, Sun ZY, Luo AX, Liang HP, Hu J, Wang ZG, Xu YS, Xu X. PLoS One. 2014 Jun 27;9(6):e100457. doi: 10.1371/journal.pone.0100457. eCollection 2014. The neuroprotective effect of Klotho is mediated via regulation of members of the redox system. Zeldich E, Chen CD, Colvin TA, Bove-Fenderson EA, Liang J, Tucker Zhou TB, Harris DA, Abraham CR. J Biol Chem. 2014 Aug 29;289(35):24700-15. doi: 10.1074/jbc.M114.567321. Epub 2014 Jul 18. Profilin-1 suppresses tumorigenicity in pancreatic cancer through regulation of the SIRT3-HIF1alpha axis. Yao W, Ji S, Qin Y, Yang J, Xu J, Zhang B, Xu W, Liu J, Shi S, Liu L, Liu C, Long J, Ni Q, Li M, Yu X. Mol Cancer. 2014 Aug 7;13:187. doi: 10.1186/1476-4598-13-187. Human coronavirus NL63 utilizes heparan sulfate proteoglycans for attachment to target cells. Myosin 5b loss of function leads to defects in polarized signaling: implication for microvillus inclusion disease pathogenesis and treatment. Am J Physiol Gastrointest Liver Physiol. 2014 Nov 15;307(10):G992-G1001. doi: 10.1152/ajpgi.00180.2014. Epub 2014 Sep 25. TET1 is a tumour suppressor that inhibits colon cancer growth by derepressing inhibitors of the WNT pathway. Neri F, Dettori D, Incarnato D, Krepelova A, Rapelli S, Maldotti M, Parlato C, Paliogiannis P, Oliviero S. Oncogene. 2014 Nov 3. doi: 10.1038/onc.2014.356. The protein phosphatase 2A inhibitor LB100 sensitizes ovarian carcinoma cells to cisplatin-mediated cytotoxicity. Mol Cancer Ther. 2015 Jan;14(1):90-100. doi: 10.1158/1535-7163.MCT-14-0496. Epub 2014 Nov 5. Asymmetric dimethylarginine exacerbates Abeta-induced toxicity and oxidative stress in human cell and Caenorhabditis elegans models of Alzheimer disease. Free Radic Biol Med. 2015 Feb;79:117-26. doi: 10.1016/j.freeradbiomed.2014.12.002. Epub 2014 Dec 12. Bayin NS, Modrek AS, Dietrich A, Lebowitz J, Abel T, Song HR, Schober M, Zagzag D, Buchholz CJ, Chao MV, Placantonakis DG. PLoS One. 2014 Dec 26;9(12):e116114. doi: 10.1371/journal.pone.0116114. eCollection 2014. Upregulated WDR5 promotes proliferation, self-renewal and chemoresistance in bladder cancer via mediating H3K4 trimethylation. Chen Y, Terajima M, Yang Y, Sun L, Ahn YH, Pankova D, Puperi DS, Watanabe T, Kim MP, Blackmon SH, Rodriguez J, Liu H, Behrens C, Wistuba II, Minelli R, Scott KL, Sanchez-Adams J, Guilak F, Pati D, Thilaganathan N, Burns AR, Creighton CJ, Martinez ED, Zal T, Grande-Allen KJ, Yamauchi M, Kurie JM. J Clin Invest. 2015 Mar 2;125(3):1147-62. doi: 10.1172/JCI74725. Epub 2015 Feb 9. The functional interactome of PYHIN immune regulators reveals IFIX is a sensor of viral DNA. Zuwala K, Golda A, Kabala W, Burmistrz M, Zdzalik M, Nowak P, Kedracka-Krok S, Zarebski M, Dobrucki J, Florek D, Zeglen S, Wojarski J, Potempa J, Dubin G, Pyrc K. PLoS One. 2015 Feb 20;10(2):e0117833. doi: 10.1371/journal.pone.0117833. eCollection 2015. Rad51-mediated replication fork reversal is a global response to genotoxic treatments in human cells. Zellweger R, Dalcher D, Mutreja K, Berti M, Schmid JA, Herrador R, Vindigni A, Lopes M. J Cell Biol. 2015 Mar 2;208(5):563-79. doi: 10.1083/jcb.201406099. ERK kinase phosphorylates and destabilizes the tumor suppressor FBW7 in pancreatic cancer. Ji S, Qin Y, Shi S, Liu X, Hu H, Zhou H, Gao J, Zhang B, Xu W, Liu J, Liang D, Liu L, Liu C, Long J, Zhou H, Chiao PJ, Xu J, Ni Q, Gao D, Yu X. Cell Res. 2015 May;25(5):561-73. doi: 10.1038/cr.2015.30. Epub 2015 Mar 10. A versatile orthotopic nude mouse model for study of esophageal squamous cell carcinoma. Reactive stroma component COL6A1 is upregulated in castration-resistant prostate cancer and promotes tumor growth. PTPRG suppresses tumor growth and invasion via inhibition of Akt signaling in nasopharyngeal carcinoma. NF-kappaB p65 Subunit Is Modulated by Latent Transforming Growth Factor-beta Binding Protein 2 (LTBP2) in Nasopharyngeal Carcinoma HONE1 and HK1 Cells. Kan R, Shuen WH, Lung HL, Cheung AK, Dai W, Kwong DL, Ng WT, Lee AW, Yau CC, Ngan RK, Tung SY, Lung ML. PLoS One. 2015 May 14;10(5):e0127239. doi: 10.1371/journal.pone.0127239. eCollection 2015. Cheng J, Li W, Kang B, Zhou Y, Song J, Dan S, Yang Y, Zhang X, Li J, Yin S, Cao H, Yao H, Zhu C, Yi W, Zhao Q, Xu X, Zheng M, Zheng S, Li L, Shen B, Wang YJ. Nat Commun. 2015 Jun 10;6:7209. doi: 10.1038/ncomms8209. Nanayakkara G, Alasmari A, Mouli S, Eldoumani H, Quindry JC, McGinnis G, Fu X, Berlin A, Peters B, Zhong J, Amin RH. Am J Physiol Heart Circ Physiol. 2015 Jun 12:ajpheart.00875.2014. doi: 10.1152/ajpheart.00875.2014. Transcription Factor ATF4 Induces NLRP1 Inflammasome Expression during Endoplasmic Reticulum Stress. PLoS One. 2015 Jun 18;10(6):e0130635. doi: 10.1371/journal.pone.0130635. eCollection 2015. The protein arginine methyltransferase PRMT5 regulates Abeta-induced toxicity in human cells and Caenorhabditis elegans models of Alzheimer s disease. Expression of the multidrug transporter P-glycoprotein is inversely related to that of apoptosis-associated endogenous TRAIL. Souza PS, Madigan JP, Gillet JP, Kapoor K, Ambudkar SV, Maia RC, Gottesman MM, Leung Fung K. Exp Cell Res. 2015 Jun 19. pii: S0014-4827(15)30013-6. doi: 10.1016/j.yexcr.2015.06.005. Disrupting NOTCH Slows Diffuse Intrinsic Pontine Glioma Growth, Enhances Radiation Sensitivity, and Shows Combinatorial Efficacy With Bromodomain Inhibition. Taylor IC, Hutt-Cabezas M, Brandt WD, Kambhampati M, Nazarian J, Chang HT, Warren KE, Eberhart CG, Raabe EH. J Neuropathol Exp Neurol. 2015 Aug;74(8):778-90. doi: 10.1097/NEN.0000000000000216. Down-regulation of poly (ADP-ribose) polymerase-1 by a viral processivity factor facilitates gammaherpesvirus lytic replication. Inhibition of class I histone deacetylases by romidepsin potently induces Epstein-Barr virus lytic cycle and mediates enhanced cell death with ganciclovir. Mouli S, Nanayakkara G, AlAlasmari A, Eldoumani H, Fu X, Berlin A, Lohani M, Nie B, Arnold RD, Kavazis A, Smith F, Beyers R, Denney T, Dhanasekaran M, Zhong J, Quindry J, Amin R. Am J Physiol Heart Circ Physiol. 2015 Sep;309(5):H844-59. doi: 10.1152/ajpheart.00182.2015. Epub 2015 Jul 24. Nuclear Localization of DNAJB6 Is Associated With Survival of Patients With Esophageal Cancer and Reduces AKT Signaling and Proliferation of Cancer Cells. Yu VZ, Wong VC, Dai W, Ko JM, Lam AK, Chan KW, Samant RS, Lung HL, Shuen WH, Law S, Chan YP, Lee NP, Tong DK, Law TT, Lee VH, Lung ML. Gastroenterology. 2015 Dec;149(7):1825-1836.e5. doi: 10.1053/j.gastro.2015.08.025. Epub 2015 Aug 22. Global Transcriptome Analysis Reveals That Poly(ADP-Ribose) Polymerase 1 Regulates Gene Expression through EZH2. Sur8/Shoc2 promotes cell motility and metastasis through activation of Ras-PI3K signaling. Hyenne V, Apaydin A, Rodriguez D, Spiegelhalter C, Hoff-Yoessle S, Diem M, Tak S, Lefebvre O, Schwab Y, Goetz JG, Labouesse M. J Cell Biol. 2015 Oct 12;211(1):27-37. doi: 10.1083/jcb.201504136. Specificity protein 4 (Sp4) transcriptionally regulates inhibitory GABAergic receptors in neurons. Biochim Biophys Acta. 2016 Jan;1863(1):1-9. doi: 10.1016/j.bbamcr.2015.10.005. Epub 2015 Oct 18. Poly(A)-specific ribonuclease (PARN) mediates 3 -end maturation of the telomerase RNA component. Bralha FN, Liyanage SU, Hurren R, Wang X, Son MH, Fung TA, Chingcuanco FB, Tung AY, Andreazza AC, Psarianos P, Schimmer AD, Salmena L, Laposa RR. Oncotarget. 2015 Nov 10;6(35):37216-28. doi: 10.18632/oncotarget.6129. Ribosome profiling reveals the rhythmic liver translatome and circadian clock regulation by upstream open reading frames. EIF2A-dependent translational arrest protects leukemia cells from the energetic stress induced by NAMPT inhibition. Zucal C, D Agostino VG, Casini A, Mantelli B, Thongon N, Soncini D, Caffa I, Cea M, Ballestrero A, Quattrone A, Indraccolo S, Nencioni A, Provenzani A. BMC Cancer. 2015 Nov 5;15:855. doi: 10.1186/s12885-015-1845-1. High-Throughput Functional Genomics Identifies Regulators of Primary Human Beta Cell Proliferation. Robitaille K, Rourke JL, McBane JE, Fu A, Baird S, Du Q, Kin T, Shapiro AM, Screaton RA. J Biol Chem. 2016 Jan 6. pii: jbc.M115.683912. Store-operated Ca2+ entry-associated regulatory factor (SARAF) plays an important role in the regulation of arachidonate-regulated Ca2+ (ARC) channels. Marmugi A, Parnis J, Chen X, Carmichael L, Hardy J, Mannan N, Marchetti P, Piemonti L, Bosco D, Johnson P, Shapiro JA, Cruciani-Guglielmacci C, Magnan C, Ibberson M, Thorens B, Valdivia HH, Rutter GA, Leclerc I. Diabetes. 2016 Apr;65(4):1009-21. doi: 10.2337/db15-1334. Epub 2016 Jan 28. Ji S, Zhang B, Liu J, Qin Y, Liang C, Shi S, Jin K, Liang D, Xu W, Xu H, Wang W, Wu C, Liu L, Liu C, Xu J, Ni Q, Yu X. Cancer Lett. 2016 Apr 28;374(1):127-35. doi: 10.1016/j.canlet.2016.01.054. Epub 2016 Feb 12. Am J Physiol Regul Integr Comp Physiol. 2016 May 1;310(9):R837-46. doi: 10.1152/ajpregu.00311.2015. Epub 2016 Feb 17. Regulatory consequences of neuronal ELAV-like protein binding to coding and non-coding RNAs in human brain. Scheckel C, Drapeau E, Frias MA, Park CY, Fak J, Zucker-Scharff I, Kou Y, Haroutunian V, Ma ayan A, Buxbaum JD, Darnell RB. Elife. 2016 Feb 19;5. pii: e10421. doi: 10.7554/eLife.10421. The membrane complement regulatory protein CD59 promotes tumor growth and predicts poor prognosis in breast cancer. Ouyang Q, Zhang L, Jiang Y, Ni X, Chen S, Ye F, Du Y, Huang L, Ding P, Wang N, Yang C, Huang T, Sun Y, Li S, Xia Y, Hu W, Luo R, Shao Z. Int J Oncol. 2016 May;48(5):2015-24. doi: 10.3892/ijo.2016.3408. Epub 2016 Feb 24. Cdk5-FOXO3a axis: initially neuroprotective, eventually neurodegenerative in Alzheimer s disease models. Zhang B, Xu J, Li C, Shi S, Ji S, Xu W, Liu J, Jin K, Liang D, Liang C, Liu L, Liu C, Qin Y, Yu X. Curr Mol Med. 2016;16(4):404-11. Shi S, Xu J, Zhang B, Ji S, Xu W, Liu J, Jin K, Liang D, Liang C, Liu L, Liu C, Qin Y, Yu X. Curr Mol Med. 2016;16(4):394-403. FBW7 (F-box and WD Repeat Domain-Containing 7) Negatively Regulates Glucose Metabolism by Targeting the c-Myc/TXNIP (Thioredoxin-Binding Protein) Axis in Pancreatic Cancer. Ji S, Qin Y, Liang C, Huang R, Shi S, Liu J, Jin K, Liang D, Xu W, Zhang B, Liu L, Liu C, Xu J, Ni Q, Chiao PJ, Li M, Yu X. Clin Cancer Res. 2016 Aug 1;22(15):3950-60. doi: 10.1158/1078-0432.CCR-15-2380. Epub 2016 Mar 16. Biochim Biophys Acta. 2016 Mar 18. pii: S0304-4165(16)30077-0. doi: 10.1016/j.bbagen.2016.03.022. Dynamic interaction of SARAF with STIM1 and Orai1 to modulate store-operated calcium entry. Albarran L, Lopez JJ, Amor NB, Martin-Cano FE, Berna-Erro A, Smani T, Salido GM, Rosado JA. Sci Rep. 2016 Apr 12;6:24452. doi: 10.1038/srep24452. TrxR2 deficiencies promote chondrogenic differentiation and induce apoptosis of chondrocytes through mitochondrial reactive oxygen species. Exp Cell Res. 2016 May 15;344(1):67-75. doi: 10.1016/j.yexcr.2016.04.014. Epub 2016 Apr 20. Tyurin-Kuzmin PA, Zhdanovskaya ND, Sukhova AA, Sagaradze GD, Albert EA, Ageeva LV, Sharonov GV, Vorotnikov AV, Tkachuk VA. PLoS One. 2016 Apr 25;11(4):e0154157. doi: 10.1371/journal.pone.0154157. eCollection 2016. The mitochondrial calcium uniporter regulates breast cancer progression via HIF-1alpha. Tosatto A, Sommaggio R, Kummerow C, Bentham RB, Blacker TS, Berecz T, Duchen MR, Rosato A, Bogeski I, Szabadkai G, Rizzuto R, Mammucari C. EMBO Mol Med. 2016 May 2;8(5):569-85. doi: 10.15252/emmm.201606255. The three Type 2A protein phosphatases, PP2Ac, PP4c and PP6c, are differentially regulated by Alpha4. Biochem Biophys Res Commun. 2016 Jun 17;475(1):64-9. doi: 10.1016/j.bbrc.2016.05.036. Epub 2016 May 8. Proc Natl Acad Sci U S A. 2016 May 24;113(21):5952-7. doi: 10.1073/pnas.1518412113. Epub 2016 May 17. A C-terminally truncated mouse Best3 splice variant targets and alters the ion balance in lysosome-endosome hybrids and the endoplasmic reticulum. The long intergenic non-coding RNA CCR492 functions as a let-7 competitive endogenous RNA to regulate c-Myc expression. Maldotti M, Incarnato D, Neri F, Krepelova A, Rapelli S, Anselmi F, Parlato C, Basile G, Dettori D, Calogero R, Oliviero S. Biochim Biophys Acta. 2016 Jun 23. pii: S1874-9399(16)30131-6. doi: 10.1016/j.bbagrm.2016.06.010. Mol Cancer Res. 2016 Sep;14(9):830-40. doi: 10.1158/1541-7786.MCR-16-0032. Epub 2016 Jul 11. Epstein-Barr Virus Oncoprotein LMP1 Mediates Epigenetic Changes in Host Gene Expression through PARP1. LIMT is a novel metastasis inhibiting lncRNA suppressed by EGF and downregulated in aggressive breast cancer. Sas-Chen A, Aure MR, Leibovich L, Carvalho S, Enuka Y, Korner C, Polycarpou-Schwarz M, Lavi S, Nevo N, Kuznetsov Y, Yuan J, Azuaje F, Ulitsky I, Diederichs S, Wiemann S, Yakhini Z, Kristensen VN, Borresen-Dale AL, Yarden Y. EMBO Mol Med. 2016 Sep 1;8(9):1052-64. doi: 10.15252/emmm.201606198. Novel biomarkers of resistance of pancreatic cancer cells to oncolytic vesicular stomatitis virus. Dynein Separately Partners with NDE1 and Dynactin To Orchestrate T Cell Focused Secretion. J Immunol. 2016 Sep 15;197(6):2090-101. doi: 10.4049/jimmunol.1600180. Epub 2016 Aug 17. Cell-Type-Specific Alternative Splicing Governs Cell Fate in the Developing Cerebral Cortex. Zhang X, Chen MH, Wu X, Kodani A, Fan J, Doan R, Ozawa M, Ma J, Yoshida N, Reiter JF, Black DL, Kharchenko PV, Sharp PA, Walsh CA. Cell. 2016 Aug 25;166(5):1147-1162.e15. doi: 10.1016/j.cell.2016.07.025. Incarnato D, Anselmi F, Morandi E, Neri F, Maldotti M, Rapelli S, Parlato C, Basile G, Oliviero S. Nucleic Acids Res. 2016 Sep 9. pii: gkw810. Whole-exome sequencing identifies multiple loss-of-function mutations of NF-kappaB pathway regulators in nasopharyngeal carcinoma. Zheng H, Dai W, Cheung AK, Ko JM, Kan R, Wong BW, Leong MM, Deng M, Kwok TC, Chan JY, Kwong DL, Lee AW, Ng WT, Ngan RK, Yau CC, Tung S, Lee VH, Lam KO, Kwan CK, Li WS, Yau S, Chan KW, Lung ML. Proc Natl Acad Sci U S A. 2016 Oct 4;113(40):11283-11288. Epub 2016 Sep 19. Targeting the metabolic pathway of human colon cancer overcomes resistance to TRAIL-induced apoptosis. Cell Death Discov. 2016 Sep 12;2:16067. doi: 10.1038/cddiscovery.2016.67. eCollection 2016. mTOR and neuronal cell cycle reentry: How impaired brain insulin signaling promotes Alzheimer s disease. Norambuena A, Wallrabe H, McMahon L, Silva A, Swanson E, Khan SS, Baerthlein D, Kodis E, Oddo S, Mandell JW, Bloom GS. Alzheimers Dement. 2016 Sep 29. pii: S1552-5260(16)32895-3. doi: 10.1016/j.jalz.2016.08.015. Reciprocal regulation of the cholinic phenotype and epithelial-mesenchymal transition in glioblastoma cells. Koch K, Hartmann R, Schroter F, Suwala AK, Maciaczyk D, Kruger AC, Willbold D, Kahlert UD, Maciaczyk J. Oncotarget. 2016 Nov 8;7(45):73414-73431. doi: 10.18632/oncotarget.12337. The High Level of Aberrant Splicing of ISCU in Slow-Twitch Muscle May Involve the Splicing Factor SRSF3. PLoS One. 2016 Oct 26;11(10):e0165453. doi: 10.1371/journal.pone.0165453. eCollection 2016. The X-Linked Autism Protein KIAA2022/KIDLIA Regulates Neurite Outgrowth via N-Cadherin and delta-Catenin Signaling. CORALINA: a universal method for the generation of gRNA libraries for CRISPR-based screening. Koferle A, Worf K, Breunig C, Baumann V, Herrero J, Wiesbeck M, Hutter LH, Gotz M, Fuchs C, Beck S, Stricker SH. BMC Genomics. 2016 Nov 14;17(1):917. Fibroblast growth factor signalling induces loss of progesterone receptor in breast cancer cells. Piasecka D, Kitowska K, Czaplinska D, Mieczkowski K, Mieszkowska M, Turczyk L, Skladanowski AC, Zaczek AJ, Biernat W, Kordek R, Romanska HM, Sadej R. Oncotarget. 2016 Dec 27;7(52):86011-86025. doi: 10.18632/oncotarget.13322. Knockdown of PTRF ameliorates adipocyte differentiation and functionality of human mesenchymal stem cells. Perez-Diaz S, Garcia-Rodriguez B, Gonzalez-Irazabal Y, Valero M, Lagos-Lizan J, Arbones-Mainar JM. Am J Physiol Cell Physiol. 2017 Jan 1;312(1):C83-C91. doi: 10.1152/ajpcell.00246.2016. Epub 2016 Nov 16. Heterogeneous nuclear ribonucleoprotein K is associated with poor prognosis and regulates proliferation and apoptosis in bladder cancer. Chen X, Gu P, Xie R, Han J, Liu H, Wang B, Xie W, Xie W, Zhong G, Chen C, Xie S, Jiang N, Lin T, Huang J. J Cell Mol Med. 2016 Nov 10. doi: 10.1111/jcmm.12999. Keyes BE, Liu S, Asare A, Naik S, Levorse J, Polak L, Lu CP, Nikolova M, Pasolli HA, Fuchs E. Cell. 2016 Nov 17;167(5):1323-1338.e14. doi: 10.1016/j.cell.2016.10.052. Kim JW, Yang HJ, Brooks MJ, Zelinger L, Karakulah G, Gotoh N, Boleda A, Gieser L, Giuste F, Whitaker DT, Walton A, Villasmil R, Barb JJ, Munson PJ, Kaya KD, Chaitankar V, Cogliati T, Swaroop A. Cell Rep. 2016 Nov 22;17(9):2460-2473. doi: 10.1016/j.celrep.2016.10.074. A permissive chromatin state regulated by ZFP281-AFF3 in controlling the imprinted Meg3 polycistron. Core binding factor (CBF) is required for Epstein-Barr virus EBNA3 proteins to regulate target gene expression. Wang L, Luo JY, Li B, Tian XY, Chen LJ, Huang Y, Liu J, Deng D, Lau CW, Wan S, Ai D, Mak KK, Tong KK, Kwan KM, Wang N, Chiu JJ, Zhu Y, Huang Y. Nature. 2016 Dec 7. doi: 10.1038/nature20602. WIP promotes in-vitro invasion ability, anchorage independent growth and EMT progression of A549 lung adenocarcinoma cells by regulating RhoA levels. Biochem Biophys Res Commun. 2017 Jan 22;482(4):1353-1359. doi: 10.1016/j.bbrc.2016.12.040. Epub 2016 Dec 7. ARF6, induced by mutant Kras, promotes proliferation and Warburg effect in pancreatic cancer. Liang C, Qin Y, Zhang B, Ji S, Shi S, Xu W, Liu J, Xiang J, Liang D, Hu Q, Ni Q, Yu X, Xu J. Cancer Lett. 2016 Dec 23;388:303-311. doi: 10.1016/j.canlet.2016.12.014. Expression of HMGB2 indicates worse survival of patients and is required for the maintenance of Warburg effect in pancreatic cancer. Acta Biochim Biophys Sin (Shanghai). 2017 Feb 6;49(2):119-127. doi: 10.1093/abbs/gmw124. Monomethyltransferase SETD8 regulates breast cancer metabolism via stabilizing hypoxia-inducible factor 1alpha. Cancer Lett. 2017 Apr 1;390:1-10. doi: 10.1016/j.canlet.2016.12.038. Epub 2017 Jan 13. Parvovirus Expresses a Small Noncoding RNA That Plays an Essential Role in Virus Replication. J Virol. 2017 Mar 29;91(8). pii: JVI.02375-16. doi: 10.1128/JVI.02375-16. Print 2017 Apr 15. Pleines I, Woods J, Chappaz S, Kew V, Foad N, Ballester-Beltran J, Aurbach K, Lincetto C, Lane RM, Schevzov G, Alexander WS, Hilton DJ, Astle WJ, Downes K, Nurden P, Westbury SK, Mumford AD, Obaji SG, Collins PW, Delerue F, Ittner LM, Bryce NS, Holliday M, Lucas CA, Hardeman EC, Ouwehand WH, Gunning PW, Turro E, Tijssen MR, Kile BT. J Clin Invest. 2017 Mar 1;127(3):814-829. doi: 10.1172/JCI86154. Epub 2017 Jan 30. Mouse Stbd1 is N-myristoylated and affects ER-mitochondria association and mitochondrial morphology. Demetriadou A, Morales-Sanfrutos J, Nearchou M, Baba O, Kyriacou K, Tate EW, Drousiotou A, Petrou PP. J Cell Sci. 2017 Mar 1;130(5):903-915. doi: 10.1242/jcs.195263. Epub 2017 Jan 30. Cdk5-Foxo3 axis: initially neuroprotective, eventually neurodegenerative in Alzheimer s disease models. A permissive chromatin state regulated by ZFP281-AFF3 in controlling the imprinted Meg3 polycistron. Incarnato D, Anselmi F, Morandi E, Neri F, Maldotti M, Rapelli S, Parlato C, Basile G, Oliviero S. Nucleic Acids Res. 2017 Feb 17;45(3):1433-1441. doi: 10.1093/nar/gkw810. Inhibition of serotonin receptor type 1 in acute myeloid leukemia impairs leukemia stem cell functionality: a promising novel therapeutic target. Etxabe A, Lara-Castillo MC, Cornet-Masana JM, Banus-Mulet A, Nomdedeu M, Torrente MA, Pratcorona M, Diaz-Beya M, Esteve J, Risueno RM. Leukemia. 2017 Nov;31(11):2288-2302. doi: 10.1038/leu.2017.52. Epub 2017 Feb 14. MR-1S Interacts with PET100 and PET117 in Module-Based Assembly of Human Cytochrome c Oxidase. Vidoni S, Harbour ME, Guerrero-Castillo S, Signes A, Ding S, Fearnley IM, Taylor RW, Tiranti V, Arnold S, Fernandez-Vizarra E, Zeviani M. Cell Rep. 2017 Feb 14;18(7):1727-1738. doi: 10.1016/j.celrep.2017.01.044. Neri F, Rapelli S, Krepelova A, Incarnato D, Parlato C, Basile G, Maldotti M, Anselmi F, Oliviero S. Nature. 2017 Mar 2;543(7643):72-77. doi: 10.1038/nature21373. Epub 2017 Feb 22. Prototype foamy virus elicits complete autophagy involving the ER stress-related UPR pathway. PDGF-induced fibroblast growth requires monounsaturated fatty acid production by stearoyl-CoA desaturase. Coomans de Brachene A, Dif N, de Rocca Serra A, Bonnineau C, Velghe AI, Larondelle Y, Tyteca D, Demoulin JB. FEBS Open Bio. 2017 Feb 2;7(3):414-423. doi: 10.1002/2211-5463.12194. eCollection 2017 Mar. Yamaji M, Jishage M, Meyer C, Suryawanshi H, Der E, Yamaji M, Garzia A, Morozov P, Manickavel S, McFarland HL, Roeder RG, Hafner M, Tuschl T. Nature. 2017 Mar 23;543(7646):568-572. doi: 10.1038/nature21690. Epub 2017 Mar 15. Silencing of the small GTPase DIRAS3 induces cellular senescence in human white adipose stromal/progenitor cells. Su X, Liu S, Zhang X, Lam SM, Hu X, Zhou Y, Chen J, Wang Y, Wu C, Shui G, Lu M, Pei R, Chen X. Biochim Biophys Acta. 2017 Jul;1862(7):692-705. doi: 10.1016/j.bbalip.2017.03.007. Epub 2017 Mar 21. SIRT6 is upregulated and associated with cancer aggressiveness in papillary thyroid cancer via BRAF/ERK/Mcl1 pathway. Hepatitis B virus PreS1 facilitates hepatocellular carcinoma development by promoting appearance and self-renewal of liver cancer stem cells. Cancer Lett. 2017 Aug 1;400:149-160. doi: 10.1016/j.canlet.2017.04.017. Epub 2017 Apr 25. Lineage tracing of dlx1a/2a and dlx5a/6a expressing cells in the developing zebrafish brain. Dev Biol. 2017 Jul 1;427(1):131-147. doi: 10.1016/j.ydbio.2017.04.019. Epub 2017 May 4. lncRNA HOXD-AS1 Regulates Proliferation and Chemo-Resistance of Castration-Resistant Prostate Cancer via Recruiting WDR5. Gu P, Chen X, Xie R, Han J, Xie W, Wang B, Dong W, Chen C, Yang M, Jiang J, Chen Z, Huang J, Lin T. Mol Ther. 2017 Aug 2;25(8):1959-1973. doi: 10.1016/j.ymthe.2017.04.016. Epub 2017 May 6. A Wnt-producing niche drives proliferative potential and progression in lung adenocarcinoma. Tammela T, Sanchez-Rivera FJ, Cetinbas NM, Wu K, Joshi NS, Helenius K, Park Y, Azimi R, Kerper NR, Wesselhoeft RA, Gu X, Schmidt L, Cornwall-Brady M, Yilmaz OH, Xue W, Katajisto P, Bhutkar A, Jacks T. Nature. 2017 May 18;545(7654):355-359. doi: 10.1038/nature22334. Epub 2017 May 10. An Ethanolic Extract of Ampelopsis Radix Exerts Anti-colorectal Cancer Effects and Potently Inhibits STAT3 Signaling In Vitro. Exogenous BDNF Increases Mitochondrial pCREB and Alleviates Neuronal Metabolic Defects Following Mechanical Injury in a MPTP-Dependent Way. Expression and prognostic value of glutamate dehydrogenase in extrahepatic cholangiocarcinoma patients. CBF1 is clinically prognostic and serves as a target to block cellular invasion and chemoresistance of EMT-like glioblastoma cells. Maciaczyk D, Picard D, Zhao L, Koch K, Herrera-Rios D, Li G, Marquardt V, Pauck D, Hoerbelt T, Zhang W, Ouwens DM, Remke M, Jiang T, Steiger HJ, Maciaczyk J, Kahlert UD. Br J Cancer. 2017 Jun 27;117(1):102-112. doi: 10.1038/bjc.2017.157. Epub 2017 Jun 1. Linaclotide activates guanylate cyclase-C/cGMP/protein kinase-II-dependent trafficking of CFTR in the intestine. Ahsan MK, Tchernychev B, Kessler MM, Solinga RM, Arthur D, Linde CI, Silos-Santiago I, Hannig G, Ameen NA. Physiol Rep. 2017 Jun;5(11). pii: 5/11/e13299. doi: 10.14814/phy2.13299. Dimethylarginine Dimethylaminohydrolase 1 Deficiency Induces the Epithelial to Mesenchymal Transition in Renal Proximal Tubular Epithelial Cells and Exacerbates Kidney Damage in Aged and Diabetic Mice. Antioxid Redox Signal. 2017 Dec 1;27(16):1347-1360. doi: 10.1089/ars.2017.7022. Epub 2017 Jul 7. BAIAP3, a C2 domain-containing Munc13 protein, controls the fate of dense-core vesicles in neuroendocrine cells. J Cell Biol. 2017 Jul 3;216(7):2151-2166. doi: 10.1083/jcb.201702099. Epub 2017 Jun 16. HOXB7 accelerates the malignant progression of hepatocellular carcinoma by promoting stemness and epithelial-mesenchymal transition. CPSF6 is a Clinically Relevant Breast Cancer Vulnerability Target: Role of CPSF6 in Breast Cancer. Overexpression of NAC1 confers drug resistance via HOXA9 in colorectal carcinoma cells. Cytosolic interaction of type III human CD38 with CIB1 modulates cellular cyclic ADP-ribose levels. The Cdk5-Mcl-1 axis promotes mitochondrial dysfunction and neurodegeneration in a model of Alzheimer s disease. Establishment of highly metastatic KRAS mutant lung cancer cell sublines in long-term three-dimensional low attachment cultures. Nakano T, Kanai Y, Amano Y, Yoshimoto T, Matsubara D, Shibano T, Tamura T, Oguni S, Katashiba S, Ito T, Murakami Y, Fukayama M, Murakami T, Endo S, Niki T. PLoS One. 2017 Aug 7;12(8):e0181342. doi: 10.1371/journal.pone.0181342. eCollection 2017. Niche-derived laminin-511 promotes midbrain dopaminergic neuron survival and differentiation through YAP. Sci Signal. 2017 Aug 22;10(493). pii: 10/493/eaal4165. doi: 10.1126/scisignal.aal4165. Hemidesmosomal linker proteins regulate cell motility, invasion and tumorigenicity in oral squamous cell carcinoma derived cells. Exp Cell Res. 2017 Nov 15;360(2):125-137. doi: 10.1016/j.yexcr.2017.08.034. Epub 2017 Sep 1. Biochem Biophys Res Commun. 2017 Nov 4;493(1):461-467. doi: 10.1016/j.bbrc.2017.08.169. Epub 2017 Sep 18. Song N, Liu ZS, Xue W, Bai ZF, Wang QY, Dai J, Liu X, Huang YJ, Cai H, Zhan XY, Han QY, Wang H, Chen Y, Li HY, Li AL, Zhang XM, Zhou T, Li T. Mol Cell. 2017 Oct 5;68(1):185-197.e6. doi: 10.1016/j.molcel.2017.08.017. Epub 2017 Sep 21. Quintero M, Adamoski D, Reis LMD, Ascencao CFR, Oliveira KRS, Goncalves KA, Dias MM, Carazzolle MF, Dias SMG. BMC Cancer. 2017 Nov 7;17(1):727. doi: 10.1186/s12885-017-3726-2. Quantitative analysis of multilayer organization of proteins and RNA in nuclear speckles at super resolution. Fei J, Jadaliha M, Harmon TS, Li ITS, Hua B, Hao Q, Holehouse AS, Reyer M, Sun Q, Freier SM, Pappu RV, Prasanth KV, Ha T. J Cell Sci. 2017 Dec 15;130(24):4180-4192. doi: 10.1242/jcs.206854. Epub 2017 Nov 13. Mayfield AE, Kanda P, Nantsios A, Parent S, Mount S, Dixit S, Ye B, Seymour R, Stewart DJ, Davis DR. Theranostics. 2017 Oct 17;7(19):4850-4861. doi: 10.7150/thno.19435. eCollection 2017. Evaluation of RNAi and CRISPR technologies by large-scale gene expression profiling in the Connectivity Map. Smith I, Greenside PG, Natoli T, Lahr DL, Wadden D, Tirosh I, Narayan R, Root DE, Golub TR, Subramanian A, Doench JG. PLoS Biol. 2017 Nov 30;15(11):e2003213. doi: 10.1371/journal.pbio.2003213. eCollection 2017 Nov. Spindle associated membrane protein 1 (Samp1) is required for the differentiation of muscle cells. SETD7 is a prognosis predicting factor of breast cancer and regulates redox homeostasis. Oncotarget. 2017 Oct 6;8(55):94080-94090. doi: 10.18632/oncotarget.21583. eCollection 2017 Nov 7. Cytoplasmic Linker Protein CLIP170 Negatively Regulates TLR4 Signaling by Targeting the TLR Adaptor Protein TIRAP. J Immunol. 2018 Jan 15;200(2):704-714. doi: 10.4049/jimmunol.1601559. Epub 2017 Dec 8. Proc Natl Acad Sci U S A. 2017 Dec 26;114(52):E11161-E11169. doi: 10.1073/pnas.1714448115. Epub 2017 Dec 11. Synthetic Lethality of Combined Bcl-2 Inhibition and p53 Activation in AML: Mechanisms and Superior Antileukemic Efficacy. ATF4 regulated by MYC has an important function in anoikis resistance in human osteosarcoma cells. Moloney leukemia virus 10 (MOV10) inhibits the degradation of APOBEC3G through interference with the Vif-mediated ubiquitin-proteasome pathway. Fok JHL, Hedayat S, Zhang L, Aronson LI, Mirabella F, Pawlyn C, Bright MD, Wardell CP, Keats JJ, De Billy E, Rye CS, Chessum NEA, Jones K, Morgan GJ, Eccles SA, Workman P, Davies FE. Clin Cancer Res. 2018 May 15;24(10):2395-2407. doi: 10.1158/1078-0432.CCR-17-1594. Epub 2018 Feb 1. Biochim Biophys Acta Gene Regul Mech. 2018 Feb;1861(2):61-71. doi: 10.1016/j.bbagrm.2018.01.008. Epub 2018 Feb 3. RIPK4/PEBP1 axis promotes pancreatic cancer cell migration and invasion by activating RAF1/MEK/ERK signaling. Qi ZH, Xu HX, Zhang SR, Xu JZ, Li S, Gao HL, Jin W, Wang WQ, Wu CT, Ni QX, Yu XJ, Liu L. Int J Oncol. 2018 Apr;52(4):1105-1116. doi: 10.3892/ijo.2018.4269. Epub 2018 Feb 7. Oncogenic Kinase-Induced PKM2 Tyrosine 105 Phosphorylation Converts Nononcogenic PKM2 to a Tumor Promoter and Induces Cancer Stem-like Cells. Cancer Res. 2018 May 1;78(9):2248-2261. doi: 10.1158/0008-5472.CAN-17-2726. Epub 2018 Feb 12. Rotaviral nonstructural protein 4 triggers dynamin-related protein 1-dependent mitochondrial fragmentation during infection. TCF7L2 positively regulates aerobic glycolysis via the EGLN2/HIF-1alpha axis and indicates prognosis in pancreatic cancer. Xiang J, Hu Q, Qin Y, Ji S, Xu W, Liu W, Shi S, Liang C, Liu J, Meng Q, Liang D, Ni Q, Xu J, Zhang B, Yu X. Cell Death Dis. 2018 Feb 23;9(3):321. doi: 10.1038/s41419-018-0367-6. Kindlin-2 regulates mesenchymal stem cell differentiation through control of YAP1/TAZ. Guo L, Cai T, Chen K, Wang R, Wang J, Cui C, Yuan J, Zhang K, Liu Z, Deng Y, Xiao G, Wu C. J Cell Biol. 2018 Apr 2;217(4):1431-1451. doi: 10.1083/jcb.201612177. Epub 2018 Mar 1. The Rab11-binding protein RELCH/KIAA1468 controls intracellular cholesterol distribution. J Cell Biol. 2018 May 7;217(5):1777-1796. doi: 10.1083/jcb.201709123. Epub 2018 Mar 7. Reshaping of the Dendritic Cell Chromatin Landscape and Interferon Pathways during HIV Infection. Johnson JS, Lucas SY, Amon LM, Skelton S, Nazitto R, Carbonetti S, Sather DN, Littman DR, Aderem A. Cell Host Microbe. 2018 Mar 14;23(3):366-381.e9. doi: 10.1016/j.chom.2018.01.012. lncRNA Epigenetic Landscape Analysis Identifies EPIC1 as an Oncogenic lncRNA that Interacts with MYC and Promotes Cell-Cycle Progression in Cancer. Cancer Cell. 2018 Apr 9;33(4):706-720.e9. doi: 10.1016/j.ccell.2018.03.006. Epub 2018 Apr 2. Conway E, Jerman E, Healy E, Ito S, Holoch D, Oliviero G, Deevy O, Glancy E, Fitzpatrick DJ, Mucha M, Watson A, Rice AM, Chammas P, Huang C, Pratt-Kelly I, Koseki Y, Nakayama M, Ishikura T, Streubel G, Wynne K, Hokamp K, McLysaght A, Ciferri C, Di Croce L, Cagney G, Margueron R, Koseki H, Bracken AP. Mol Cell. 2018 May 3;70(3):408-421.e8. doi: 10.1016/j.molcel.2018.03.005. Epub 2018 Apr 5. CD10 inhibits cell motility but expression is associated with advanced stage disease in colorectal cancer. Raposo TP, Comes MS, Idowu A, Agit B, Hassall J, Fadhil W, Nica R, Ecker R, Yao T, Ilyas M. Exp Mol Pathol. 2018 Jun;104(3):190-198. doi: 10.1016/j.yexmp.2018.04.002. Epub 2018 Apr 11. GCN2 deficiency ameliorates doxorubicin-induced cardiotoxicity by decreasing cardiomyocyte apoptosis and myocardial oxidative stress. CBX3 promotes proliferation and regulates glycolysis via suppressing FBP1 in pancreatic cancer. Biochem Biophys Res Commun. 2018 Jun 7;500(3):691-697. doi: 10.1016/j.bbrc.2018.04.137. Epub 2018 Apr 22. Yes-associated protein mediates human embryonic stem cell-derived cardiomyocyte proliferation: Involvement of epidermal growth factor receptor signaling. AMPKalpha2 deficiency exacerbates long-term PM2.5 exposure-induced lung injury and cardiac dysfunction. Wang H, Shen X, Tian G, Shi X, Huang W, Wu Y, Sun L, Peng C, Liu S, Huang Y, Chen X, Zhang F, Chen Y, Ding W, Lu Z. Free Radic Biol Med. 2018 Jun;121:202-214. doi: 10.1016/j.freeradbiomed.2018.05.008. Epub 2018 May 10. Rivera C, Zandonadi FS, Sanchez-Romero C, Soares CD, Granato DC, Gonzalez-Arriagada WA, Paes Leme AF. Br J Cancer. 2018 Jun;118(12):1628-1638. doi: 10.1038/s41416-018-0135-5. Epub 2018 Jun 6. CARM1 Is Essential for Myeloid Leukemogenesis but Dispensable for Normal Hematopoiesis. Greenblatt SM, Man N, Hamard PJ, Asai T, Karl D, Martinez C, Bilbao D, Stathias V, Jermakowicz AM, Duffort S, Tadi M, Blumenthal E, Newman S, Vu L, Xu Y, Liu F, Schurer SC, McCabe MT, Kruger RG, Xu M, Yang FC, Tenen DG, Watts J, Vega F, Nimer SD. Cancer Cell. 2018 Jun 11;33(6):1111-1127.e5. doi: 10.1016/j.ccell.2018.05.007. Zhang TT, Qu N, Sun GH, Zhang L, Wang YJ, Mu XM, Wei WJ, Wang YL, Wang Y, Ji QH, Zhu YX, Shi RL. Int J Oncol. 2018 Aug;53(2):685-693. doi: 10.3892/ijo.2018.4426. Epub 2018 May 31. Alpha protocadherins and Pyk2 kinase regulate cortical neuron migration and cytoskeletal dynamics via Rac1 GTPase and WAVE complex in mice. Actomyosin stress fiber subtypes have unique viscoelastic properties and roles in tension generation. Mol Biol Cell. 2018 Aug 8;29(16):1992-2004. doi: 10.1091/mbc.E18-02-0106. Epub 2018 Jun 21. Frontal Bone Healing Is Sensitive to Wnt Signaling Inhibition via Lentiviral-Encoded Beta-Catenin Short Hairpin RNA. Zhang L, Chang L, Xu J, Meyers CA, Yan N, Zou E, Ding C, Ting K, Soo C, Pang S, James AW. Tissue Eng Part A. 2018 Aug 20. doi: 10.1089/ten.TEA.2017.0465. J Cell Biol. 2018 Aug 6;217(8):2877-2890. doi: 10.1083/jcb.201710132. Epub 2018 Jun 21. Mol Neurobiol. 2019 Feb;56(2):1366-1390. doi: 10.1007/s12035-018-1114-9. Epub 2018 Jun 8. Genome-scale analysis identifies paralog lethality as a vulnerability of chromosome 1p loss in cancer. Viswanathan SR, Nogueira MF, Buss CG, Krill-Burger JM, Wawer MJ, Malolepsza E, Berger AC, Choi PS, Shih J, Taylor AM, Tanenbaum B, Pedamallu CS, Cherniack AD, Tamayo P, Strathdee CA, Lage K, Carr SA, Schenone M, Bhatia SN, Vazquez F, Tsherniak A, Hahn WC, Meyerson M. Nat Genet. 2018 Jul;50(7):937-943. doi: 10.1038/s41588-018-0155-3. Epub 2018 Jun 28. CBFbeta-SMMHC Inhibition Triggers Apoptosis by Disrupting MYC Chromatin Dynamics in Acute Myeloid Leukemia. Pulikkan JA, Hegde M, Ahmad HM, Belaghzal H, Illendula A, Yu J, O Hagan K, Ou J, Muller-Tidow C, Wolfe SA, Zhu LJ, Dekker J, Bushweller JH, Castilla LH. Cell. 2018 Jun 28;174(1):172-186.e21. doi: 10.1016/j.cell.2018.05.048. GCN2 deficiency protects against high fat diet induced hepatic steatosis and insulin resistance in mice. Biochim Biophys Acta Mol Basis Dis. 2018 Oct;1864(10):3257-3267. doi: 10.1016/j.bbadis.2018.07.012. Epub 2018 Jul 11. Risk SNP-Mediated Promoter-Enhancer Switching Drives Prostate Cancer through lncRNA PCAT19. Hua JT, Ahmed M, Guo H, Zhang Y, Chen S, Soares F, Lu J, Zhou S, Wang M, Li H, Larson NB, McDonnell SK, Patel PS, Liang Y, Yao CQ, van der Kwast T, Lupien M, Feng FY, Zoubeidi A, Tsao MS, Thibodeau SN, Boutros PC, He HH. Cell. 2018 Jul 26;174(3):564-575.e18. doi: 10.1016/j.cell.2018.06.014. Epub 2018 Jul 19. The actin filament bundling protein alpha-actinin-4 actually suppresses actin stress fibers by permitting actin turnover. J Biol Chem. 2018 Sep 14;293(37):14520-14533. doi: 10.1074/jbc.RA118.004345. Epub 2018 Jul 26. Padilla-Rodriguez M, Parker SS, Adams DG, Westerling T, Puleo JI, Watson AW, Hill SM, Noon M, Gaudin R, Aaron J, Tong D, Roe DJ, Knudsen B, Mouneimne G. Nat Commun. 2018 Jul 30;9(1):2980. doi: 10.1038/s41467-018-05367-2. A metabolic interplay coordinated by HLX regulates myeloid differentiation and AML through partly overlapping pathways. Piragyte I, Clapes T, Polyzou A, Klein Geltink RI, Lefkopoulos S, Yin N, Cauchy P, Curtis JD, Klaeyle L, Langa X, Beckmann CCA, Wlodarski MW, Muller P, Van Essen D, Rambold A, Kapp FG, Mione M, Buescher JM, Pearce EL, Polyzos A, Trompouki E. Nat Commun. 2018 Aug 6;9(1):3090. doi: 10.1038/s41467-018-05311-4. Circ-BPTF promotes bladder cancer progression and recurrence through the miR-31-5p/RAB27A axis. Positive Regulation of Transcription by Human ZMYND8 through Its Association with P-TEFb Complex. Sweeney JG, Liang J, Antonopoulos A, Giovannone N, Kang S, Mondala TS, Head SR, King SL, Tani Y, Brackett D, Dell A, Murphy GF, Haslam SM, Widlund HR, Dimitroff CJ. Nat Commun. 2018 Aug 22;9(1):3368. doi: 10.1038/s41467-018-05795-0. Rapamycin Upregulates Connective Tissue Growth Factor Expression in Hepatic Progenitor Cells Through TGF-beta-Smad2 Dependent Signaling. A DNA-sensing-independent role of a nuclear RNA helicase, DHX9, in stimulation of NF-kappaB-mediated innate immunity against DNA virus infection. The tuberous sclerosis complex subunit TBC1D7 is stabilized by Akt phosphorylation-mediated 14-3-3 binding. Madigan JP, Hou F, Ye L, Hu J, Dong A, Tempel W, Yohe ME, Randazzo PA, Jenkins LMM, Gottesman MM, Tong Y. J Biol Chem. 2018 Oct 19;293(42):16142-16159. doi: 10.1074/jbc.RA118.003525. Epub 2018 Aug 24. HIV-1 intron-containing RNA expression induces innate immune activation and T cell dysfunction. G protein pathway suppressor 2 (GPS2) links inflammation and cholesterol efflux by controlling lipopolysaccharide-induced ATP-binding cassette transporter A1 expression in macrophages. Crebbp Loss Drives Small Cell Lung Cancer and Increases Sensitivity to HDAC Inhibition. Jia D, Augert A, Kim DW, Eastwood E, Wu N, Ibrahim AH, Kim KB, Dunn CT, Pillai SPS, Gazdar AF, Bolouri H, Park KS, MacPherson D. Cancer Discov. 2018 Nov;8(11):1422-1437. doi: 10.1158/2159-8290.CD-18-0385. Epub 2018 Sep 4. Co-activation of super-enhancer-driven CCAT1 by TP63 and SOX2 promotes squamous cancer progression. Jiang Y, Jiang YY, Xie JJ, Mayakonda A, Hazawa M, Chen L, Xiao JF, Li CQ, Huang ML, Ding LW, Sun QY, Xu L, Kanojia D, Jeitany M, Deng JW, Liao LD, Soukiasian HJ, Berman BP, Hao JJ, Xu LY, Li EM, Wang MR, Bi XG, Lin DC, Koeffler HP. Nat Commun. 2018 Sep 6;9(1):3619. doi: 10.1038/s41467-018-06081-9. Histone deacetylase 2 is essential for LPS-induced inflammatory responses in macrophages. PTBP1 acts as a dominant repressor of the aberrant tissue-specific splicing of ISCU in hereditary myopathy with lactic acidosis. Mol Genet Genomic Med. 2018 Nov;6(6):887-897. doi: 10.1002/mgg3.413. Epub 2018 Sep 12. Transaminase Inhibition by 2-Hydroxyglutarate Impairs Glutamate Biosynthesis and Redox Homeostasis in Glioma. McBrayer SK, Mayers JR, DiNatale GJ, Shi DD, Khanal J, Chakraborty AA, Sarosiek KA, Briggs KJ, Robbins AK, Sewastianik T, Shareef SJ, Olenchock BA, Parker SJ, Tateishi K, Spinelli JB, Islam M, Haigis MC, Looper RE, Ligon KL, Bernstein BE, Carrasco RD, Cahill DP, Asara JM, Metallo CM, Yennawar NH, Vander Heiden MG, Kaelin WG Jr. Cell. 2018 Sep 20;175(1):101-116.e25. doi: 10.1016/j.cell.2018.08.038. Epub 2018 Sep 13. lncRNA LINC01296 regulates the proliferation, metastasis and cell cycle of osteosarcoma through cyclin D1. Vimentin and Non-Muscle Myosin IIA are Members of the Neural Precursor Cell Expressed Developmentally Down-Regulated 9 (NEDD9) Interactome in Head and Neck Squamous Cell Carcinoma Cells. Semelakova M, Grauzam S, Betadthunga P, Tiedeken J, Coaxum S, Neskey DM, Rosenzweig SA. Transl Oncol. 2019 Jan;12(1):49-61. doi: 10.1016/j.tranon.2018.09.006. Epub 2018 Sep 26. Omer Javed A, Li Y, Muffat J, Su KC, Cohen MA, Lungjangwa T, Aubourg P, Cheeseman IM, Jaenisch R. Cell Rep. 2018 Oct 9;25(2):368-382.e5. doi: 10.1016/j.celrep.2018.09.032. SNX6 predicts poor prognosis and contributes to the metastasis of pancreatic cancer cells via activating epithelial-mesenchymal transition. Hu P, Liang Y, Hu Q, Wang H, Cai Z, He J, Cai J, Liu M, Qin Y, Yu X, Jiang C, Zhang B, Wang W. Acta Biochim Biophys Sin (Shanghai). 2018 Nov 1;50(11):1075-1084. doi: 10.1093/abbs/gmy110. PIN1 Maintains Redox Balance via the c-Myc/NRF2 Axis to Counteract Kras-Induced Mitochondrial Respiratory Injury in Pancreatic Cancer Cells. Liang C, Shi S, Liu M, Qin Y, Meng Q, Hua J, Ji S, Zhang Y, Yang J, Xu J, Ni Q, Li M, Yu X. Cancer Res. 2019 Jan 1;79(1):133-145. doi: 10.1158/0008-5472.CAN-18-1968. Epub 2018 Oct 24. Hao H, Hao S, Chen H, Chen Z, Zhang Y, Wang J, Wang H, Zhang B, Qiu J, Deng F, Guan W. Nucleic Acids Res. 2019 Jan 10;47(1):362-374. doi: 10.1093/nar/gky1007. Delivery of shRNA via lentivirus in human pseudoislets provides a model to test dynamic regulation of insulin secretion and gene function in human islets. Reversal of ApoE4-induced recycling block as a novel prevention approach for Alzheimer s disease. Xian X, Pohlkamp T, Durakoglugil MS, Wong CH, Beck JK, Lane-Donovan C, Plattner F, Herz J. Elife. 2018 Oct 30;7. pii: 40048. doi: 10.7554/eLife.40048. Atkinson A, Renziehausen A, Wang H, Lo Nigro C, Lattanzio L, Merlano M, Rao B, Weir L, Evans A, Matin R, Harwood C, Szlosarek P, Pickering JG, Fleming C, Sim VR, Li S, Vasta JT, Raines RT, Boniol M, Thompson A, Proby C, Crook T, Syed N. J Invest Dermatol. 2018 Nov 16. pii: S0022-202X(18)32822-7. doi: 10.1016/j.jid.2018.10.038. RA-839, a selective agonist of Nrf2/ARE pathway, exerts potent anti-rotaviral efficacy in vitro. Antiviral Res. 2019 Jan;161:53-62. doi: 10.1016/j.antiviral.2018.11.009. Epub 2018 Nov 19. Shihabudeen Haider Ali MS, Cheng X, Moran M, Haemmig S, Naldrett MJ, Alvarez S, Feinberg MW, Sun X. Nucleic Acids Res. 2018 Nov 22. pii: 5198489. doi: 10.1093/nar/gky1190. Albarran L, Lopez JJ, Jardin I, Sanchez-Collado J, Berna-Erro A, Smani T, Camello PJ, Salido GM, Rosado JA. Cell Physiol Biochem. 2018;51(3):1164-1178. doi: 10.1159/000495494. Epub 2018 Nov 27. Zinc finger E-box-binding homeobox 1 mediates aerobic glycolysis via suppression of sirtuin 3 in pancreatic cancer. AFF3-DNA methylation interplay in maintaining the mono-allelic expression pattern of XIST in terminally differentiated cells. GPx1 is involved in the induction of protective autophagy in pancreatic cancer cells in response to glucose deprivation. Przystal JM, Hajji N, Khozoie C, Renziehausen A, Zeng Q, Abaitua F, Hajitou A, Suwan K, Want E, Bomalaski J, Szlosarek P, O Neill K, Crook T, Syed N. Cell Death Dis. 2018 Dec 13;9(12):1192. doi: 10.1038/s41419-018-1195-4. CCNG1 (Cyclin G1) regulation by mutant-P53 via induction of Notch3 expression promotes high-grade serous ovarian cancer (HGSOC) tumorigenesis and progression. High PLK4 expression promotes tumor progression and induces epithelialmesenchymal transition by regulating the Wnt/betacatenin signaling pathway in colorectal cancer. Liao Z, Zhang H, Fan P, Huang Q, Dong K, Qi Y, Song J, Chen L, Liang H, Chen X, Zhang Z, Zhang B. Int J Oncol. 2019 Feb;54(2):479-490. doi: 10.3892/ijo.2018.4659. Epub 2018 Dec 10. DHHC4 and DHHC5 Facilitate Fatty Acid Uptake by Palmitoylating and Targeting CD36 to the Plasma Membrane. Wang J, Hao JW, Wang X, Guo H, Sun HH, Lai XY, Liu LY, Zhu M, Wang HY, Li YF, Yu LY, Xie C, Wang HR, Mo W, Zhou HM, Chen S, Liang G, Zhao TJ. Cell Rep. 2019 Jan 2;26(1):209-221.e5. doi: 10.1016/j.celrep.2018.12.022. BRCA2 deficiency instigates cGAS-mediated inflammatory signaling and confers sensitivity to tumor necrosis factor-alpha-mediated cytotoxicity. Heijink AM, Talens F, Jae LT, van Gijn SE, Fehrmann RSN, Brummelkamp TR, van Vugt MATM. Nat Commun. 2019 Jan 9;10(1):100. doi: 10.1038/s41467-018-07927-y. Dickkopf-3 links HSF1 and YAP/TAZ signalling to control aggressive behaviours in cancer-associated fibroblasts. Ferrari N, Ranftl R, Chicherova I, Slaven ND, Moeendarbary E, Farrugia AJ, Lam M, Semiannikova M, Westergaard MCW, Tchou J, Magnani L, Calvo F. Nat Commun. 2019 Jan 10;10(1):130. doi: 10.1038/s41467-018-07987-0. Requirement for PRC1 subunit BMI1 in host gene activation by Epstein-Barr virus protein EBNA3C. Guo H, Ci X, Ahmed M, Hua JT, Soares F, Lin D, Puca L, Vosoughi A, Xue H, Li E, Su P, Chen S, Nguyen T, Liang Y, Zhang Y, Xu X, Xu J, Sheahan AV, Ba-Alawi W, Zhang S, Mahamud O, Vellanki RN, Gleave M, Bristow RG, Haibe-Kains B, Poirier JT, Rudin CM, Tsao MS, Wouters BG, Fazli L, Feng FY, Ellis L, van der Kwast T, Berlin A, Koritzinsky M, Boutros PC, Zoubeidi A, Beltran H, Wang Y, He HH. Nat Commun. 2019 Jan 17;10(1):278. doi: 10.1038/s41467-018-08133-6. Loss of BCAA Catabolism during Carcinogenesis Enhances mTORC1 Activity and Promotes Tumor Development and Progression. Ericksen RE, Lim SL, McDonnell E, Shuen WH, Vadiveloo M, White PJ, Ding Z, Kwok R, Lee P, Radda GK, Toh HC, Hirschey MD, Han W. Cell Metab. 2019 May 7;29(5):1151-1165.e6. doi: 10.1016/j.cmet.2018.12.020. Epub 2019 Jan 17. Multivalent Role of Human TFIID in Recruiting Elongation Components at the Promoter-Proximal Region for Transcriptional Control. Chen S, Huang V, Xu X, Livingstone J, Soares F, Jeon J, Zeng Y, Hua JT, Petricca J, Guo H, Wang M, Yousif F, Zhang Y, Donmez N, Ahmed M, Volik S, Lapuk A, Chua MLK, Heisler LE, Foucal A, Fox NS, Fraser M, Bhandari V, Shiah YJ, Guan J, Li J, Orain M, Picard V, Hovington H, Bergeron A, Lacombe L, Fradet Y, Tetu B, Liu S, Feng F, Wu X, Shao YW, Komor MA, Sahinalp C, Collins C, Hoogstrate Y, de Jong M, Fijneman RJA, Fei T, Jenster G, van der Kwast T, Bristow RG, Boutros PC, He HH. Cell. 2019 Feb 7;176(4):831-843.e22. doi: 10.1016/j.cell.2019.01.025. The transcription factor TFCP2L1 induces expression of distinct target genes and promotes self-renewal of mouse and human embryonic stem cells. J Biol Chem. 2019 Apr 12;294(15):6007-6016. doi: 10.1074/jbc.RA118.006341. Epub 2019 Feb 19. Guo L, Cui C, Zhang K, Wang J, Wang Y, Lu Y, Chen K, Yuan J, Xiao G, Tang B, Sun Y, Wu C. Nat Commun. 2019 Feb 19;10(1):845. doi: 10.1038/s41467-019-08772-3. Mammalian Pum1 and Pum2 Control Body Size via Translational Regulation of the Cell Cycle Inhibitor Cdkn1b. Lin K, Qiang W, Zhu M, Ding Y, Shi Q, Chen X, Zsiros E, Wang K, Yang X, Kurita T, Xu EY. Cell Rep. 2019 Feb 26;26(9):2434-2450.e6. doi: 10.1016/j.celrep.2019.01.111. MicroRNA-Mediated Suppression of the TGF-beta Pathway Confers Transmissible and Reversible CDK4/6 Inhibitor Resistance. Collaborative ISL1/GATA3 interaction in controlling neuroblastoma oncogenic pathways overlapping with but distinct from MYCN. Zhang Q, Zhang Q, Jiang X, Ye Y, Liao H, Zhu F, Yan J, Luo L, Tian L, Jiang C, Chen Y, Liang X, Sun Y. Theranostics. 2019 Jan 30;9(4):986-1000. doi: 10.7150/thno.30199. eCollection 2019. PRMT5 enhances tumorigenicity and glycolysis in pancreatic cancer via the FBW7/cMyc axis. Qin Y, Hu Q, Xu J, Ji S, Dai W, Liu W, Xu W, Sun Q, Zhang Z, Ni Q, Zhang B, Yu X, Xu X. Cell Commun Signal. 2019 Mar 29;17(1):30. doi: 10.1186/s12964-019-0344-4. A Subset of TREM2(+) Dermal Macrophages Secretes Oncostatin M to Maintain Hair Follicle Stem Cell Quiescence and Inhibit Hair Growth. Cell Stem Cell. 2019 Apr 4;24(4):654-669.e6. doi: 10.1016/j.stem.2019.01.011. Epub 2019 Mar 28. Charting DENR-dependent translation reinitiation uncovers predictive uORF features and links to circadian timekeeping via Clock. Structure and Degradation of Circular RNAs Regulate PKR Activation in Innate Immunity. Liu CX, Li X, Nan F, Jiang S, Gao X, Guo SK, Xue W, Cui Y, Dong K, Ding H, Qu B, Zhou Z, Shen N, Yang L, Chen LL. Cell. 2019 May 2;177(4):865-880.e21. doi: 10.1016/j.cell.2019.03.046. Epub 2019 Apr 25. Amot and Yap1 regulate neuronal dendritic tree complexity and locomotor coordination in mice. Rojek KO, Krzemien J, Dolezyczek H, Boguszewski PM, Kaczmarek L, Konopka W, Rylski M, Jaworski J, Holmgren L, Proszynski TJ. PLoS Biol. 2019 May 1;17(5):e3000253. doi: 10.1371/journal.pbio.3000253. eCollection 2019 May. CRISPR/Cas9 System for Efficient Genome Editing and Targeting in the Mouse NIH/3T3 Cells. Gene-centric functional dissection of human genetic variation uncovers regulators of hematopoiesis. Nandakumar SK, McFarland SK, Mateyka LM, Lareau CA, Ulirsch JC, Ludwig LS, Agarwal G, Engreitz JM, Przychodzen B, McConkey M, Cowley GS, Doench JG, Maciejewski JP, Ebert BL, Root DE, Sankaran VG. Elife. 2019 May 9;8. pii: 44080. doi: 10.7554/eLife.44080. Baumann V, Wiesbeck M, Breunig CT, Braun JM, Koferle A, Ninkovic J, Gotz M, Stricker SH. Nat Commun. 2019 May 9;10(1):2119. doi: 10.1038/s41467-019-10146-8. Cytosolic translational responses differ under conditions of severe short-term and long-term mitochondrial stress. Samluk L, Urbanska M, Kisielewska K, Mohanraj K, Kim MJ, Machnicka K, Liszewska E, Jaworski J, Chacinska A. Mol Biol Cell. 2019 Jul 15;30(15):1864-1877. doi: 10.1091/mbc.E18-10-0628. Epub 2019 May 22. A novel YAP1/SLC35B4 regulatory axis contributes to proliferation and progression of gastric carcinoma. Liu J, Zhao X, Wang K, Zhang X, Yu Y, Lv Y, Zhang S, Zhang L, Guo Y, Li Y, Yang A, Zhang R, Li J. Cell Death Dis. 2019 Jun 7;10(6):452. doi: 10.1038/s41419-019-1674-2. Regulation of lactate production through p53/beta-enolase axis contributes to statin-associated muscle symptoms. EBioMedicine. 2019 Jul;45:251-260. doi: 10.1016/j.ebiom.2019.06.003. Epub 2019 Jun 11. DEPTOR induces a partial epithelial-to-mesenchymal transition and metastasis via autocrine TGFbeta1 signaling and is associated with poor prognosis in hepatocellular carcinoma. Chen J, Zhu H, Liu Q, Ning D, Zhang Z, Zhang L, Mo J, Du P, Liu X, Song S, Fan Y, Liang H, Liu J, Zhang B, Chen X. J Exp Clin Cancer Res. 2019 Jun 22;38(1):273. doi: 10.1186/s13046-019-1220-1. DIPK2A promotes STX17- and VAMP7-mediated autophagosome-lysosome fusion by binding to VAMP7B. CRISPR-Cas9 Mediated TSPO Gene Knockout alters Respiration and Cellular Metabolism in Human Primary Microglia Cells. Milenkovic VM, Slim D, Bader S, Koch V, Heinl ES, Alvarez-Carbonell D, Nothdurfter C, Rupprecht R, Wetzel CH. Int J Mol Sci. 2019 Jul 9;20(13). pii: ijms20133359. doi: 10.3390/ijms20133359. Deacetylation of beta-catenin by SIRT1 regulates self-renewal and oncogenesis of liver cancer stem cells. Cancer Lett. 2019 Oct 28;463:1-10. doi: 10.1016/j.canlet.2019.07.021. Epub 2019 Aug 5. Barroso-Gonzalez J, Garcia-Exposito L, Hoang SM, Lynskey ML, Roncaioli JL, Ghosh A, Wallace CT, Modesti M, Bernstein KA, Sarkar SN, Watkins SC, O Sullivan RJ. Mol Cell. 2019 Oct 3;76(1):11-26.e7. doi: 10.1016/j.molcel.2019.06.043. Epub 2019 Aug 7. p63 and SOX2 Dictate Glucose Reliance and Metabolic Vulnerabilities in Squamous Cell Carcinomas. Hsieh MH, Choe JH, Gadhvi J, Kim YJ, Arguez MA, Palmer M, Gerold H, Nowak C, Do H, Mazambani S, Knighton JK, Cha M, Goodwin J, Kang MK, Jeong JY, Lee SY, Faubert B, Xuan Z, Abel ED, Scafoglio C, Shackelford DB, Minna JD, Singh PK, Shulaev V, Bleris L, Hoyt K, Kim J, Inoue M, DeBerardinis RJ, Kim TH, Kim JW. Cell Rep. 2019 Aug 13;28(7):1860-1878.e9. doi: 10.1016/j.celrep.2019.07.027. Biphasic regulation of RNA interference during rotavirus infection by modulation of Argonaute2. Targeting plasma membrane phosphatidylserine content to inhibit oncogenic KRAS function. Life Sci Alliance. 2019 Aug 26;2(5). pii: 2/5/e201900431. doi: 10.26508/lsa.201900431. Print 2019 Oct. Concomitant targeting of Hedgehog signaling and MCL-1 synergistically induces cell death in Hedgehog-driven cancer cells. Cancer Lett. 2019 Nov 28;465:1-11. doi: 10.1016/j.canlet.2019.08.012. Epub 2019 Aug 26. Defects in t(6)A tRNA modification due to GON7 and YRDC mutations lead to Galloway-Mowat syndrome. Arrondel C, Missoury S, Snoek R, Patat J, Menara G, Collinet B, Liger D, Durand D, Gribouval O, Boyer O, Buscara L, Martin G, Machuca E, Nevo F, Lescop E, Braun DA, Boschat AC, Sanquer S, Guerrera IC, Revy P, Parisot M, Masson C, Boddaert N, Charbit M, Decramer S, Novo R, Macher MA, Ranchin B, Bacchetta J, Laurent A, Collardeau-Frachon S, van Eerde AM, Hildebrandt F, Magen D, Antignac C, van Tilbeurgh H, Mollet G. Nat Commun. 2019 Sep 3;10(1):3967. doi: 10.1038/s41467-019-11951-x. Microglial Pro-Inflammatory and Anti-Inflammatory Phenotypes Are Modulated by Translocator Protein Activation. Pozzo ED, Tremolanti C, Costa B, Giacomelli C, Milenkovic VM, Bader S, Wetzel CH, Rupprecht R, Taliani S, Settimo FD, Martini C. Int J Mol Sci. 2019 Sep 10;20(18). pii: ijms20184467. doi: 10.3390/ijms20184467. MBD1 promotes the malignant behavior of gallbladder cancer cells and induces chemotherapeutic resistance to gemcitabine. Wensheng L, Bo Z, Qiangsheng H, Wenyan X, Shunrong J, Jin X, Quanxing N, Xianjun Y, Xiaowu X. Cancer Cell Int. 2019 Sep 9;19:232. doi: 10.1186/s12935-019-0948-1. eCollection 2019. Increased proton-sensing receptor GPR4 signalling promotes colorectal cancer progression by activating the hippo pathway. EBioMedicine. 2019 Oct;48:264-276. doi: 10.1016/j.ebiom.2019.09.016. Epub 2019 Sep 14. Human PI3Kgamma deficiency and its microbiota-dependent mouse model reveal immunodeficiency and tissue immunopathology. Takeda AJ, Maher TJ, Zhang Y, Lanahan SM, Bucklin ML, Compton SR, Tyler PM, Comrie WA, Matsuda M, Olivier KN, Pittaluga S, McElwee JJ, Long Priel DA, Kuhns DB, Williams RL, Mustillo PJ, Wymann MP, Koneti Rao V, Lucas CL. Nat Commun. 2019 Sep 25;10(1):4364. doi: 10.1038/s41467-019-12311-5. A PINCH-1-Smurf1 signaling axis mediates mechano-regulation of BMPR2 and stem cell differentiation. J Cell Biol. 2019 Nov 4;218(11):3773-3794. doi: 10.1083/jcb.201902022. Epub 2019 Oct 2. Endothelial PKA activity regulates angiogenesis by limiting autophagy through phosphorylation of ATG16L1. Zhao X, Nedvetsky P, Stanchi F, Vion AC, Popp O, Zuhlke K, Dittmar G, Klussmann E, Gerhardt H. Elife. 2019 Oct 3;8. pii: 46380. doi: 10.7554/eLife.46380. Targeting Wnt/EZH2/microRNA-708 signaling pathway inhibits neuroendocrine differentiation in prostate cancer. Shan J, Al-Muftah MA, Al-Kowari MK, Abuaqel SWJ, Al-Rumaihi K, Al-Bozom I, Li P, Chouchane L. Cell Death Discov. 2019 Sep 30;5:139. doi: 10.1038/s41420-019-0218-y. eCollection 2019. Int J Biol Sci. 2019 Aug 24;15(11):2350-2362. doi: 10.7150/ijbs.34450. eCollection 2019. Centrosome Amplification in Cancer Disrupts Autophagy and Sensitizes to Autophagy Inhibition. Mol Cancer Res. 2020 Jan;18(1):33-45. doi: 10.1158/1541-7786.MCR-19-0509. Epub 2019 Oct 11. TFPa/HADHA is required for fatty acid beta-oxidation and cardiolipin re-modeling in human cardiomyocytes. Miklas JW, Clark E, Levy S, Detraux D, Leonard A, Beussman K, Showalter MR, Smith AT, Hofsteen P, Yang X, Macadangdang J, Manninen T, Raftery D, Madan A, Suomalainen A, Kim DH, Murry CE, Fiehn O, Sniadecki NJ, Wang Y, Ruohola-Baker H. Nat Commun. 2019 Oct 11;10(1):4671. doi: 10.1038/s41467-019-12482-1. Carboxypeptidase A6 Promotes the Proliferation and Migration of Hepatocellular Carcinoma by Up-regulating AKT Signaling Pathway. Curr Med Sci. 2019 Oct;39(5):727-733. doi: 10.1007/s11596-019-2098-z. Epub 2019 Oct 14. AGR2 is controlled by DNMT3a-centered signaling module and mediates tumor resistance to 5-Aza in colorectal cancer. Li J, Hu J, Luo Z, Zhou C, Huang L, Zhang H, Chi J, Chen Z, Li Q, Deng M, Chen J, Tao K, Wang G, Wang L, Wang Z. Exp Cell Res. 2019 Dec 1;385(1):111644. doi: 10.1016/j.yexcr.2019.111644. Epub 2019 Oct 12. Oxidative DNA damage is concurrently repaired by base excision repair (BER) and apyrimidinic endonuclease 1 (APE1)-initiated nonhomologous end joining (NHEJ) in cortical neurons. Neuropathol Appl Neurobiol. 2020 Jun;46(4):375-390. doi: 10.1111/nan.12584. Epub 2019 Nov 6. Knockdown Of TRIM31 Enhances Colorectal Cancer Radiosensitivity By Inducing DNA Damage And Activating Apoptosis. Onco Targets Ther. 2019 Oct 3;12:8179-8188. doi: 10.2147/OTT.S215769. eCollection 2019. Metformin protects against PM2.5-induced lung injury and cardiac dysfunction independent of AMP-activated protein kinase alpha2. Microbiol Immunol. 2020 Feb;64(2):143-152. doi: 10.1111/1348-0421.12756. Epub 2019 Nov 20. NEXMIF/KIDLIA Knock-out Mouse Demonstrates Autism-Like Behaviors, Memory Deficits, and Impairments in Synapse Formation and Function. Gilbert J, O Connor M, Templet S, Moghaddam M, Di Via Ioschpe A, Sinclair A, Zhu LQ, Xu W, Man HY. J Neurosci. 2020 Jan 2;40(1):237-254. doi: 10.1523/JNEUROSCI.0222-19.2019. Epub 2019 Nov 8. Mark1 regulates distal airspace expansion through type I pneumocyte flattening in lung development. Genome-wide suppressor screen identifies USP35/USP38 as therapeutic candidates for ciliopathies. Barrier-to-autointegration factor 1 (Banf1) regulates poly [ADP-ribose] polymerase 1 (PARP1) activity following oxidative DNA damage. Bolderson E, Burgess JT, Li J, Gandhi NS, Boucher D, Croft LV, Beard S, Plowman JJ, Suraweera A, Adams MN, Naqi A, Zhang SD, Sinclair DA, O Byrne KJ, Richard DJ. Nat Commun. 2019 Dec 3;10(1):5501. doi: 10.1038/s41467-019-13167-5. Foxall E, Staszowska A, Hirvonen LM, Georgouli M, Ciccioli M, Rimmer A, Williams L, Calle Y, Moreno VS, Cox S, Jones GE, Wells CM. Cell Rep. 2019 Dec 10;29(11):3385-3393.e6. doi: 10.1016/j.celrep.2019.11.016. Transcriptome analysis-identified long noncoding RNA CRNDE in maintaining endothelial cell proliferation, migration, and tube formation. Moran M, Cheng X, Shihabudeen Haider Ali MS, Wase N, Nguyen N, Yang W, Zhang C, DiRusso C, Sun X. Sci Rep. 2019 Dec 20;9(1):19548. doi: 10.1038/s41598-019-56030-9. RAD51 is a potential marker for prognosis and regulates cell proliferation in pancreatic cancer. Cancer Cell Int. 2019 Dec 27;19:356. doi: 10.1186/s12935-019-1077-6. eCollection 2019. Dynein-mediated nuclear translocation of yes-associated protein through microtubule acetylation controls fibroblast activation. Cell Mol Life Sci. 2020 Jan 7. pii: 10.1007/s00018-019-03412-x. doi: 10.1007/s00018-019-03412-x. Fas-apoptotic inhibitory molecule 2 localizes to the lysosome and facilitates autophagosome-lysosome fusion through the LC3 interaction region motif-dependent interaction with LC3. FOXE1 represses cell proliferation and Warburg effect by inhibiting HK2 in colorectal cancer. Angiomotin links ROCK and YAP signaling in mechanosensitive differentiation of neural stem cells. Mol Biol Cell. 2020 Mar 1;31(5):386-396. doi: 10.1091/mbc.E19-11-0602. Epub 2020 Jan 15. Madigan JP, Robey RW, Poprawski JE, Huang H, Clarke CJ, Gottesman MM, Cabot MC, Rosenberg DW. Exp Cell Res. 2020 Mar 15;388(2):111860. doi: 10.1016/j.yexcr.2020.111860. Epub 2020 Jan 20. The m6A reader YTHDF1 promotes ovarian cancer progression via augmenting EIF3C translation. Liu T, Wei Q, Jin J, Luo Q, Liu Y, Yang Y, Cheng C, Li L, Pi J, Si Y, Xiao H, Li L, Rao S, Wang F, Yu J, Yu J, Zou D, Yi P. Nucleic Acids Res. 2020 Apr 17;48(7):3816-3831. doi: 10.1093/nar/gkaa048. Loss of hnRNPA2B1 inhibits malignant capability and promotes apoptosis via down-regulating Lin28B expression in ovarian cancer. Yang Y, Wei Q, Tang Y, Yuanyuan Wang, Luo Q, Zhao H, He M, Wang H, Zeng Q, Lu W, Xu J, Liu T, Yi P. Cancer Lett. 2020 Apr 10;475:43-52. doi: 10.1016/j.canlet.2020.01.029. Epub 2020 Jan 29. Roscovitine enhances All-trans retinoic acid (ATRA)-induced leukemia cell differentiation: Novel effects on signaling molecules for a putative Cdk2 inhibitor. Autophagic Degradation of NBR1 Restricts Metastatic Outgrowth during Mammary Tumor Progression. Marsh T, Kenific CM, Suresh D, Gonzalez H, Shamir ER, Mei W, Tankka A, Leidal AM, Kalavacherla S, Woo K, Werb Z, Debnath J. Dev Cell. 2020 Mar 9;52(5):591-604.e6. doi: 10.1016/j.devcel.2020.01.025. Epub 2020 Feb 20. Identification of NOVA family proteins as novel beta-catenin RNA-binding proteins that promote epithelial-mesenchymal transition. RNA Biol. 2020 Jun;17(6):881-891. doi: 10.1080/15476286.2020.1734372. Epub 2020 Mar 4. Luo H, Yu Q, Liu Y, Tang M, Liang M, Zhang D, Xiao TS, Wu L, Tan M, Ruan Y, Bungert J, Lu J. Sci Adv. 2020 Feb 19;6(8):eaaw4651. doi: 10.1126/sciadv.aaw4651. eCollection 2020 Feb. Identification of scavenger receptor B1 as the airway microfold cell receptor for Mycobacterium tuberculosis. Khan HS, Nair VR, Ruhl CR, Alvarez-Arguedas S, Galvan Rendiz JL, Franco LH, Huang L, Shaul PW, Kim J, Xie Y, Mitchell RB, Shiloh MU. Elife. 2020 Mar 5;9. pii: 52551. doi: 10.7554/eLife.52551. MiR-377-3p suppresses colorectal cancer through negative regulation on Wnt/beta-catenin signaling by targeting XIAP and ZEB2. Pharmacol Res. 2020 Jun;156:104774. doi: 10.1016/j.phrs.2020.104774. Epub 2020 Mar 24. Reciprocal expression of trefoil factor-1 and thyroid transcription factor-1 in lung adenocarcinomas. Matsubara D, Yoshimoto T, Soda M, Amano Y, Kihara A, Funaki T, Ito T, Sakuma Y, Shibano T, Endo S, Hagiwara K, Ishikawa S, Fukayama M, Murakami Y, Mano H, Niki T. Cancer Sci. 2020 Jun;111(6):2183-2195. doi: 10.1111/cas.14403. Epub 2020 Apr 30. Roscovitine enhances all-trans retinoic acid (ATRA)-induced nuclear enrichment of an ensemble of activated signaling molecules and augments ATRA-induced myeloid cell differentiation. Oncotarget. 2020 Mar 24;11(12):1017-1036. doi: 10.18632/oncotarget.27508. eCollection 2020 Mar 24. Aurora Borealis (Bora), Which Promotes Plk1 Activation by Aurora A, Has an Oncogenic Role in Ovarian Cancer. Parrilla A, Barber M, Majem B, Castellvi J, Morote J, Sanchez JL, Perez-Benavente A, Segura MF, Gil-Moreno A, Santamaria A. Cancers (Basel). 2020 Apr 6;12(4). pii: cancers12040886. doi: 10.3390/cancers12040886. Trophectoderm-Specific Knockdown of LIN28 Decreases Expression of Genes Necessary for Cell Proliferation and Reduces Elongation of Sheep Conceptus. A genetic screen identifies Crat as a regulator of pancreatic beta-cell insulin secretion. Berdous D, Berney X, Sanchez-Archidona AR, Jan M, Roujeau C, Lopez-Mejia IC, Mynatt R, Thorens B. Mol Metab. 2020 Jul;37:100993. doi: 10.1016/j.molmet.2020.100993. Epub 2020 Apr 13. Progressive Rotavirus Infection Downregulates Redox-Sensitive Transcription Factor Nrf2 and Nrf2-Driven Transcription Units. Oxid Med Cell Longev. 2020 Apr 4;2020:7289120. doi: 10.1155/2020/7289120. eCollection 2020. Hsp90 facilitates acquired drug resistance of tumor cells through cholesterol modulation however independent of tumor progression. Biochim Biophys Acta Mol Cell Res. 2020 Aug;1867(8):118728. doi: 10.1016/j.bbamcr.2020.118728. Epub 2020 Apr 25. Pin1 promotes pancreatic cancer progression and metastasis by activation of NF-kappaB-IL-18 feedback loop. Sun Q, Fan G, Zhuo Q, Dai W, Ye Z, Ji S, Xu W, Liu W, Hu Q, Zhang Z, Liu M, Yu X, Xu X, Qin Y. Cell Prolif. 2020 May;53(5):e12816. doi: 10.1111/cpr.12816. Epub 2020 Apr 29. LSD1-mediated enhancer silencing attenuates retinoic acid signalling during pancreatic endocrine cell development. Vinckier NK, Patel NA, Geusz RJ, Wang A, Wang J, Matta I, Harrington AR, Wortham M, Wetton N, Wang J, Jhala US, Rosenfeld MG, Benner CW, Shih HP, Sander M. Nat Commun. 2020 Apr 29;11(1):2082. doi: 10.1038/s41467-020-16017-x. Enhanced glutamine utilization mediated by SLC1A5 and GPT2 is an essential metabolic feature of colorectal signet ring cell carcinoma with therapeutic potential. Abrogation of ARF6 promotes RSL3-induced ferroptosis and mitigates gemcitabine resistance in pancreatic cancer cells. Ye Z, Hu Q, Zhuo Q, Zhu Y, Fan G, Liu M, Sun Q, Zhang Z, Liu W, Xu W, Ji S, Yu X, Xu X, Qin Y. Am J Cancer Res. 2020 Apr 1;10(4):1182-1193. eCollection 2020. Cancers (Basel). 2020 May 2;12(5). pii: cancers12051141. doi: 10.3390/cancers12051141. Discrete functional and mechanistic roles of chromodomain Y-like 2 (CDYL2) transcript variants in breast cancer growth and metastasis. RNA Biol. 2020 Jul;17(7):1040-1052. doi: 10.1080/15476286.2020.1755112. Epub 2020 May 7. Li Y, Shan Y, Kilaru GK, Berto S, Wang GZ, Cox KH, Yoo SH, Yang S, Konopka G, Takahashi JS. Elife. 2020 May 27;9. pii: 54186. doi: 10.7554/eLife.54186. SRPK1 acetylation modulates alternative splicing to regulate cisplatin resistance in breast cancer cells. miR-486 is involved in the pathogenesis of acute myeloid leukemia by regulating JAK-STAT signaling. Naunyn Schmiedebergs Arch Pharmacol. 2020 May 29. pii: 10.1007/s00210-020-01892-4. doi: 10.1007/s00210-020-01892-4. Effects of Inorganic Arsenic on Human Prostate Stem-Progenitor Cell Transformation, Autophagic Flux Blockade, and NRF2 Pathway Activation. Environ Health Perspect. 2020 Jun;128(6):67008. doi: 10.1289/EHP6471. Epub 2020 Jun 11. The human box C/D snoRNA U3 is a miRNA source and miR-U3 regulates expression of sortin nexin 27. Y Chromosome LncRNA are involved in Radiation Response of Male Non-Small Cell Lung Cancer Cells. Brownmiller T, Juric JA, Ivey AD, Harvey BM, Westemeier ES, Winters MT, Stevens AM, Stanley AN, Hayes KE, Sprowls SA, Gatesman Ammer AS, Walker M, Bey EA, Wu X, Lim ZF, Zhu L, Wen S, Hu G, Ma PC, Martinez I. Cancer Res. 2020 Jul 2. pii: 0008-5472.CAN-19-4032. doi: 10.1158/0008-5472.CAN-19-4032. Induction and Regulation of the Immunoproteasome Subunit beta5i (PSMB8) in Laryngeal and Hypopharyngeal Carcinoma Cells. Analysis of the centrosome-ome identifies MCPH1 deletion as a cause of centrosome amplification in human cancer. The matrix metalloproteinase 7 (MMP7) links Hsp90 chaperone with acquired drug resistance and tumor metastasis. Splicing variation of BMP2K balances abundance of COPII assemblies and autophagic degradation in erythroid cells. Cendrowski J, Kaczmarek M, Mazur M, Kuzmicz-Kowalska K, Jastrzebski K, Brewinska-Olchowik M, Kominek A, Piwocka K, Miaczynska M. Elife. 2020 Aug 14;9. pii: 58504. doi: 10.7554/eLife.58504. Li Y, Ivica NA, Dong T, Papageorgiou DP, He Y, Brown DR, Kleyman M, Hu G, Chen WW, Sullivan LB, Del Rosario A, Hammond PT, Vander Heiden MG, Chen J. Nat Commun. 2020 Sep 24;11(1):4837. doi: 10.1038/s41467-020-18607-1. ABRO1 stabilizes the deubiquitinase BRCC3 through inhibiting its degradation mediated by the E3 ubiquitin ligase WWP2. Zhang W, Tao SS, Wang T, Zhang J, Liu X, Li YT, Chen H, Zhan YQ, Yu M, Ge CH, Li CY, Ren GM, Yang XM, Yin RH. FEBS Lett. 2021 Jan;595(2):169-182. doi: 10.1002/1873-3468.13970. Epub 2020 Nov 8. CEBPG promotes esophageal squamous cell carcinoma progression by enhancing PI3K-AKT signaling. Kallikrein 13 serves as a priming protease during infection by the human coronavirus HKU1. Milewska A, Falkowski K, Kulczycka M, Bielecka E, Naskalska A, Mak P, Lesner A, Ochman M, Urlik M, Diamandis E, Prassas I, Potempa J, Kantyka T, Pyrc K. Sci Signal. 2020 Nov 24;13(659). pii: 13/659/eaba9902. doi: 10.1126/scisignal.aba9902. Cell Signal. 2021 Apr;80:109907. doi: 10.1016/j.cellsig.2020.109907. Epub 2020 Dec 28. Optimized RNA-targeting CRISPR/Cas13d technology outperforms shRNA in identifying functional circRNAs. 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